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Retention Time of Four Common Poisons (Drugs) by GC-MS Qualitative Analysis.
Fa Yi Xue za Zhi 2018 June
OBJECTIVES: To investigate the maximum allowable deviation of retention time (RT) or relative retention time (RRT) between the common poisons (drugs) and standard solvent by gas chromatography-mass spectrometry (GC-MS).
METHODS: After pretreatment with liquid-liquid extraction, four common poisons (drugs)-dichlorvos, phorate, diazepam and estazolam-were detected by full scan mode GC-MS. RT and RRT were analyzed according to combined uncertainty and expanded uncertainty.
RESULTS: The expanded uncertainty of RT and RRT were 6.0×10-4 -14.1×10-3 and 2.5×10-6 -5.9×10-5 ( k =3), respectively. The RT of poisons (drugs) was relatively stable in blood samples with different mass concentrations. Among dichlorvos, phorate, diazepam and estazolam, the absolute deviation and relative deviation of RT were ≤0.03 min and ≤0.4%, respectively, and those of RRT were ≤0.003 min and ≤0.3%, respectively.
CONCLUSIONS: The maximum allowable deviations of RT and RRT for common poisons (drugs) in blood samples are recommended to be ±0.05 min and ±0.5%.
METHODS: After pretreatment with liquid-liquid extraction, four common poisons (drugs)-dichlorvos, phorate, diazepam and estazolam-were detected by full scan mode GC-MS. RT and RRT were analyzed according to combined uncertainty and expanded uncertainty.
RESULTS: The expanded uncertainty of RT and RRT were 6.0×10-4 -14.1×10-3 and 2.5×10-6 -5.9×10-5 ( k =3), respectively. The RT of poisons (drugs) was relatively stable in blood samples with different mass concentrations. Among dichlorvos, phorate, diazepam and estazolam, the absolute deviation and relative deviation of RT were ≤0.03 min and ≤0.4%, respectively, and those of RRT were ≤0.003 min and ≤0.3%, respectively.
CONCLUSIONS: The maximum allowable deviations of RT and RRT for common poisons (drugs) in blood samples are recommended to be ±0.05 min and ±0.5%.
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