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Defining the immunogram of breast cancer: a focus on clinical trials.
Expert Opinion on Biological Therapy 2019 March 21
In the phase III ImPassion130 trial the addition of immunotherapy to chemotherapy improved overall survival in mTNBC patients. This benefit was significant only in patients harboring PD-L1-positive tumors, suggesting that stratification according to response biomarkers is needed to achieve consistent responses. Besides PD-L1 expression, a variety of potential biomarkers are under investigation for predicting immunotherapy efficacy in breast cancer, such as tumor-infiltrating lymphocytes, gene signatures, tumor mutational burden, microsatellite instability and gut microbiome. Enriching future trials through these biomarkers could help identifying the population of responders, realizing what has been called precision immunotherapy.
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