Read by QxMD icon Read

Chitosan-TPP Nanoparticles Stabilized by Poloxamer for Controlling the Release and Enhancing the Bioavailability of Doxazosin Mesylate: In Vitro, and In Vivo Evaluation

Bader M Aljaeid, Khalid M El-Say, Khaled M Hosny
Drug Development and Industrial Pharmacy 2019 March 18, : 1-30

OBJECTIVE: Control the release and enhance the bioavailability of chitosan-doxazosin mesylate nanoparticles (DM-NPs).

SIGNIFICANCE: Improve DM bioavailability for the treatment of benign prostatic hyperplasia and hypertension.

METHODS: Plackett-Burman design was utilized to screen the variables affecting the quality of DM-NPs prepared by ionic gelation method. The investigated variables were initial drug load (X1 ), chitosan percentage (X2 ), tripolyphosphate sodium (TPP) percentage (X3 ), poloxamer percentage (X4 ), homogenization speed (X5 ), homogenization time (X6 ) and TPP addition rate (X7 ). The prepared DM-loaded NPs have been fully evaluated for particle size (Y1 ), Zeta potential (Y2 ), production yield (Y3 ), entrapment efficiency (Y4 ), loading capacity (Y5 ), initial burst (Y6 ), and cumulative drug release (Y7 ). Finally, DM pharmacokinetic has been investigated on healthy albino male rabbits by means of non-compartmental analysis.

RESULTS: The combination of variables showed variability of Y1 , Y2 , and Y3 equal to 122-710 nm, 3.49-23.63 mV, and 47.31-92.96%, respectively. While Y4 and Y5 , reached 99.87%, and 8.53%, respectively. The prepared NPs revealed that X2 , X3 , and X4 are the variables that play the important role in controlling the release behavior of DM from the NPs. The in vivo pharmacokinetic results indicated the enhancement in bioavailability of DM by 7 folds compared to drug suspension and the mean residence time prolonged to 23.72 h compared to 4.7 h of drug suspension.

CONCLUSIONS: The study proved that controlling the release of DM from NPs enhance its bioavailability and improve the compliance of patients with hypertension or benign prostatic hyperplasia.


You need to log in or sign up for an account to be able to comment.

No comments yet, be the first to post one!

Related Papers

Available on the App Store

Available on the Play Store
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"