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Effectiveness and Safety of Ustekinumab 90 mg in Patients Weighing 100 kg or less: A Retrospective, Observational, Multicenter Study.

BACKGROUND: Scant information from clinical practice is available on the effectiveness and safety of ustekinumab (UST) 90mg in patients with psoriasis weighing 100kg or less.

OBJECTIVES: To assess the effectiveness and safety at weeks 16 and 24 of UST 90 mg in patients with psoriasis weighing ≤100kg, and to study the impact on clinical outcomes of body mass index and prior exposure to UST 45mg.

METHODS: A retrospective, observational, multicenter study of 74 adult patients who were treated with UST 90mg at least 24 weeks.

RESULTS: Mean (SD) score on PASI was 7.9 (4.8) at baseline, 3.3 (3.5) at week 16, and 2.2 (2.4) at week 24, when 69.7% of the patients had a PASI under 3. Overweight and obese patients achieved a mean PASI of 2.2 by week 24 (P = 0.995). In patients who had previously been treated with UST 45mg (52/74) with insufficient response, mean (SD) absolute PASI score was 2.7 (2.6) at week 24. No serious adverse events were reported.

CONCLUSION: In patients who weigh 100kg or less but are overweight or obese and do not present an adequate response with UST 45mg, increasing the dose to UST 90mg could be an alternative option.

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