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Injury affects coelomic fluid proteome of the common starfish Asterias rubens .
Journal of Experimental Biology 2019 March 16
Echinoderms, possessing outstanding regenerative capabilities, provide a unique model system for the study of response to injury. However, there is little known about the proteomic composition of coelomic fluid, an important biofluid circulating throughout the animal's body and reflecting the overall biological status of the organism. In this study, we used LC-MALDI tandem mass spectrometry to characterize the proteome of the cell-free coelomic fluid of starfish Asterias rubens and to follow the changes occurring in response to puncture wound and blood loss. In total, 91 proteins were identified, of which 61 were extracellular soluble and 16 were bound to the plasma membrane. Most represented functional terms were "pattern recognition receptor activity" and "peptidase inhibitor activity". A series of candidate proteins involved in early response to injury was revealed. Ependymin, β-microseminoprotein, serum amyloid A, and avidin-like proteins, which are known to be involved in intestinal regeneration in sea cucumber, were also identified as injury-responsive proteins. Our results expand the list of proteins potentially involved in defense and regeneration in echinoderms and demonstrate dramatic effects of injury on the CF proteome.
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