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Cerebral Peduncle Volume and Motor Function Following Adult Hemispherectomy.

World Neurosurgery 2019 March 13
BACKGROUND: Hemispherectomy is a successful and well described treatment option for pediatric patients with hemispheric ictal onset, but adult outcomes have been far less studied. We describe the outcomes for adult patients with medically refractory epilepsy and hemispheric disease and the relationship to cerebral peduncle volume.

CASE DESCRIPTIONS: We retrospectively reviewed adult hemispherectomy patients at our institution from 2015 to 2018. Patient data including demographic information, pathology, seizure-free outcomes, and ipsilateral (i.e., surgical side) and contralateral (i.e., functional side) cerebral peduncle volume data were collected. We identified 4 adult patients who underwent hemispherectomy. The mean age at surgery was roughly 25 years. All patients were categorized as Engel I or II, and motor scores at last follow-up were unchanged. The mean volume for contralateral and ipsilateral cerebral peduncle means were 1.42 and 0.78 cm3 respectively (p = 0.01).

CONCLUSION: These findings suggested that smaller ipsilateral cerebral peduncle size could potentially be associated with unchanged postoperative hemiparesis. We hypothesize that smaller ipsilateral peduncle size could have represented corticospinal tract reorganization in childhood, implying that the removed brain matter was mostly non-contributory to contralateral motor function.

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