Add like
Add dislike
Add to saved papers

In Silico Performance of a Recellularized Tissue Engineered Transcatheter Aortic Valve.

Commercially available heart valves have many limitations, such as a lack of re-modeling, risk of calcification and thromboembolic problems. Many state-of-the-art tissue engineered heart valves rely on recellularization. Current in vitro testing is insufficient in characterizing a soon to be living valve. It is imperative to understand the performance of an in situ valve, but due to the complex in vivo environment this is difficult to accomplish. Finite element analysis has become a standard tool for modeling mechanical behavior of heart valves; yet, research to date has mostly focused on commercial valves. The purpose of this study has been to develop finite element models of a decellularized and recellularized tissue engineered heart valve. Mechanical properties from porcine aortic valves were utilized to develop finite element models, which were run through a full physiological cardiac cycle. Maximum principal stresses and strains from the leaflets and commissures were analyzed. The results of this study demonstrate that the explanted tissues had reduced mechanical strength compared to the implants but were similar to the native tissues. For the finite element models the explanted recellularized leaflets showed lower stress but increased compliance in the leaflet belly compared to native tissues and higher compliance than implant tissues. Histology demonstrated recellularization and remodeling although remodeled collagen had no clear directionality. In conclusion, we observed successful recellularization and remodeling of the tissue, however, the mechanical response indicates the further remodeling is required following implantation in the aortic/pulmonary position.

Full text links

We have located links that may give you full text access.
Can't access the paper?
Try logging in through your university/institutional subscription. For a smoother one-click institutional access experience, please use our mobile app.

For the best experience, use the Read mobile app

Mobile app image

Get seemless 1-tap access through your institution/university

For the best experience, use the Read mobile app

All material on this website is protected by copyright, Copyright © 1994-2024 by WebMD LLC.
This website also contains material copyrighted by 3rd parties.

By using this service, you agree to our terms of use and privacy policy.

Your Privacy Choices Toggle icon

You can now claim free CME credits for this literature searchClaim now

Get seemless 1-tap access through your institution/university

For the best experience, use the Read mobile app