Benign liver tumors

Benign liver tumors diagnosis. Benign liver tumors are rare events that affect mostly young women. Hepatic hemangioma and focal nodular hyperplasia are not related to oral contraceptions, nor associated with complications, and consequently should not either be treated or followed-up. Liver imaging (mainly MRI with contrast agent) is often sufficient to perform the diagnosis of these benign liver tumors, but in case of doubtful diagnosis or underlying liver diseases, expert advice is needed to discuss liver biopsy. Hepatocellular adenomas (HCA) are oestrogen-dependent benign liver tumors and include 6 different molecular subtypes. MRI helps to characterize hepatocellular adenoma, but histological analysis is often needed to confirm the diagnosis and to guide therapeutic decision. Clinical management of hepatocellular adenomas required a multidisciplinary tumor board. Estrogens should be stopped in all patients and surgical resection is indicated in male or if the tumor size is > 5 cm or if HCA harbored mutation in â-catenin due to the high risk of malignant transformation.