We have located links that may give you full text access.
Persistence of smoking induced non-small cell lung carcinogenesis by decreasing ERBB pathway-related microRNA expression.
Thoracic Cancer 2019 March 14
BACKGROUND: Tobacco use is responsible for approximately 80-90% of non-small cell lung cancer cases. A large evidence base has shown that the ERBB pathway is associated with the occurrence of lung cancer. However, the mechanisms of how smoking activates the ERBB pathway have yet to be explained. We hypothesized that microRNAs may induce ERBB pathway activity during the process of lung cancer carcinogenesis.
METHODS: We analyzed microRNA array data from the Gene Expression Omnibus and the Kyoto Encyclopedia of Genes and Genomes to determine any associations between genes and smoking in three groups of patients with NSCLC: smokers, former smokers, and non-smokers.
RESULTS: The interaction network among miRNAs, including hsa-mir-185-3p, hsa-mir-4295, hsa-mir-4288, and hsa-mir-613, promotes lung cancer development by affecting the ERBB pathway.
CONCLUSION: Our findings provide evidence to explain the mechanism of lung cancer development in smokers.
METHODS: We analyzed microRNA array data from the Gene Expression Omnibus and the Kyoto Encyclopedia of Genes and Genomes to determine any associations between genes and smoking in three groups of patients with NSCLC: smokers, former smokers, and non-smokers.
RESULTS: The interaction network among miRNAs, including hsa-mir-185-3p, hsa-mir-4295, hsa-mir-4288, and hsa-mir-613, promotes lung cancer development by affecting the ERBB pathway.
CONCLUSION: Our findings provide evidence to explain the mechanism of lung cancer development in smokers.
Full text links
Related Resources
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app
All material on this website is protected by copyright, Copyright © 1994-2024 by WebMD LLC.
This website also contains material copyrighted by 3rd parties.
By using this service, you agree to our terms of use and privacy policy.
Your Privacy Choices
You can now claim free CME credits for this literature searchClaim now
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app