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Visualization of large vessel occlusion, clot extent, and collateral supply using volume perfusion flat detector computed tomography in acute stroke patients

Philip Hoelter, Philipp Goelitz, Stefan Lang, Hannes Luecking, Bernd Kalmuenzer, Tobias Struffert, Arnd Doerfler
Acta Radiologica 2019 March 12, : 284185119836220

BACKGROUND: Flat detector computed tomography angiography (FDCTA) can be reconstructed from volume perfusion flat detector computed tomography (VP-FDCT). Thus, CTA equivalent stroke imaging might be feasible within the angio suite.

PURPOSE: To evaluate the diagnostic accuracy of FDCTA in detecting large vessel occlusion (LVO) and collateral supply in acute stroke patients.

MATERIAL AND METHODS: Sixteen patients with LVO of the anterior circulation were analyzed retrospectively. Each patient underwent a multimodal CT stroke protocol, subsequent VP-FDCT, and digital subtraction angiography (DSA) for endovascular stroke therapy. Angiographic images reconstructed secondarily from VP-FDCT were evaluated with regard to visualization of LVO, Collateral Score (CS), Clot Burden Score (CBS), and image quality.

RESULTS: Image quality of FDCTA was sufficient for diagnosis with a strong correlation between CTA and FDCTA (median score: CTA = 4 ± 0.447; FDCTA = 4 ± 0.5). Detection of LVO could be achieved with high sensitivity and specificity for FDCTA and CTA (97.9%, 95% confidence interval [CI] = 96.0-99.9; 92.6%, 95% CI = 84.3-100.0 vs. 96.8%, 95% CI = 93.2-100.0; 86.3%, 95% CI = 88.2-95.2). CBS and CS assessment showed no significant difference between FDCTA and CTA for both readers (reader1CBS : P = 0.751, reader1CS : P = 0.718; reader2CBS : P = 0.164; reader2CS : P = 0.582) and an excellent interrater agreement (CTACBS ICC = 0.984, FDCTACBS ICC = 0.951; CTACS ICC = 0.754, FDCTACS ICC = 0.789).

CONCLUSION: FDCTA, reconstructed from VP-FDCT data, allows reliable detection of ICA or MCA M1 segment occlusion comparable to CTA and may provide information concerning the clot extent with sufficient image quality.


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