Advancement in TPL2-regulated innate immune response

Ming-Hao Yan, Jun-Hong Hao, Xue-Gang Zhang, Chao-Chao Shen, Da-Jun Zhang, Ke-Shan Zhang, Hai-Xue Zheng, Xiang-Tao Liu
Immunobiology 2019 March 5
Tumor progression locus 2 (TPL2) is a serine/threonine kinase that belongs to the MAP3K family. The activated TPL2 regulates the innate immune-relevant signaling pathways, such as ERK, JNK, and NF-κB, and the differentiation of immune cells, for example, CD4+ T and NK cells. Therefore, TPL2 plays a critical role in regulating the innate immune response. The present review summarizes the recent advancements in the TPL2-regulated innate immune response.

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