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Potentially beneficial effects of rhamnose on skin aging: an in vitro and in vivo study.
International Journal of Cosmetic Science 2019 March 8
OBJECTIVE: Recent findings showed that skin aging preferentially affects human papillary dermal fibroblasts suggesting that the papillary dermis represents a critical zone altered by skin aging. Based on these findings, we investigated the potential anti-aging effect of Rhamnose.
METHODS: We investigated the potential anti-aging effect of Rhamnose using in vitro reconstructed skin containing fibroblasts obtained either from young or old donors, and in vivo clinical investigation.
RESULTS: We detected positive effects of Rhamnose in both epidermal and dermal compartments of in vitro reconstructed skin. Moreover, we were able to show that such in vitro findings were also obtained in vivo including an effect on collagen IV and procollagen I production.
CONCLUSION: We provide evidence that Rhamnose has a potentially beneficial effect on papillary dermis and dermal epidermal junction which are both area affected by skin aging. This article is protected by copyright. All rights reserved.
METHODS: We investigated the potential anti-aging effect of Rhamnose using in vitro reconstructed skin containing fibroblasts obtained either from young or old donors, and in vivo clinical investigation.
RESULTS: We detected positive effects of Rhamnose in both epidermal and dermal compartments of in vitro reconstructed skin. Moreover, we were able to show that such in vitro findings were also obtained in vivo including an effect on collagen IV and procollagen I production.
CONCLUSION: We provide evidence that Rhamnose has a potentially beneficial effect on papillary dermis and dermal epidermal junction which are both area affected by skin aging. This article is protected by copyright. All rights reserved.
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