Curcumin-Silk Fibroin Nanoparticles for Enhanced Anti- Candida albicans Activity In Vitro and In Vivo

Baiji Xue, Yuelan Zhang, Man Xu, Chuqiao Wang, Jinxiang Huang, Haoxiang Zhang, Shuhui Meng, Maobin Xie, Ailin Tao, Xuefeng Li
Journal of Biomedical Nanotechnology 2019 April 1, 15 (4): 769-778
Curcumin (CM) has multiple pharmacological activities including anti-fungal activity, but its clinical application is limited due to low solubility in aqueous media, poor bioavailability and extensive first pass metabolism. We aimed to resolve the limitation and enhance antifungal activity of CM using nanotechnology. Using silk fibroin (SF) as a carrier, we fabricated curcumin-silk fibroin nanoparticles (CM-SF NPs) by solution enhanced dispersion of supercritical CO₂ (SEDS) technique. The characterization of CM-SF NPs was analyzed using scanning electron microscopy (SEM), fourier transform infrared spectroscopy (FTIR), differential scanning calorimeter (DSC) and thermo gravimetric apparatus (TGA). Following characterization of the NPs, we evaluated the antifungal activity of CM-SF NPs against Candida albicans in vitro and in vivo . A SF-based drug delivery system (CM-SF NPs, 85 ± 15 nm) was established by SEDS. Compared to original CM, water solubility of CM-SF NPs was improved, and its antifungal activity was enhanced. The natural compound-loaded SF nanoparticles may be a promising therapeutic candidate for fungal infection.

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