Synthesis and characterization of Valcyclovir HCl hybrid solid lipid nanoparticles by using Natural oils.

BACKGROUND: The Jojoba Simmondsia Chinensis oil is used as one of the main ingredients which have an antioxidant, moisturizing and stabilizing activity. Likewise, grape seed (Vitis vinifera) oil is also used in this preparation which also has some remarkable medicinal properties such as antioxidant, astringent and as a moisturizer. The Valacyclovir solid lipid nanoparticles (SLN) were prepared in combination.

OBJECTIVE: The prime objective of the study is to prepare a nano dispersion with good stability indicating zeta potential. The formulations were prepared by varying concentrations of jojoba oil and grape seed oil which forms the hybrid nanoparticles with drug.

METHOD: The high-pressure hot-homogenization technique was used to prepare the nanoparticles. The prepared nanoparticles were subjected to characterization analysis such as Mean particle size, Z-average, and Zeta potential by using dynamic light scattering (DLS) and photon correlation spectroscopy (PCS). The best formulation was subjected to Transmission electron microscopy (TEM) technique for surface morphology and other characterization. The crystalline pattern of the drug alone, drug-loaded nanoparticles and nanoparticles without the drug were studied by XRD. The drug excipients compatibility studies were performed by using Fourier-transform infrared spectroscopy (FTIR) Differential Scanning Calorimetry and (DSC). The other studies such as in vitro drug release, % drug entrapment efficiency were studied by using suitable methods.

RESULTS: The results demonstrated that the particles are in nano range with good stability with appreciable Zeta potential (-48.2±mV). The selected formulations were analyzed for MPS which demonstrated the value of 306.7±183.4 and 416.5±289.3. The best formulation VNP5 demonstrated the Bell-shaped curve and confirmed the uniform distribution. Based on the patents, it was demonstrated that, valacyclovir is widely used in the treatment and prophylaxis of viral infections in human, particularly infections caused by herpes group of viruses. Valacyclovir is an effective drug for treatment of Cold sores.