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Pediatric Diffuse Large B-Cell Lymphoma of the Frontal Sinus: A Case Report

Sean Allen Knudson, Kristopher M Day, Raymond J Harshbarger
Cleft Palate-craniofacial Journal 2019 March 5, : 1055665619831165
An 11-year-old male presented with right proptosis, bulbar conjunctivitis, and diplopia. Computerized tomography (CT) and magnetic resonance imaging revealed an enhancing mass involving the superio-medial orbit, ethmoids, frontal sinus, and anterior cranial fossa with skull base destruction. Diffuse large B-cell lymphoma was diagnosed via CT-guided biopsy. As a component of multidisciplinary care, the patient underwent frontal sinus cranialization, with orbital and skull base reconstruction. Trauma reconstructive principles guided recreation of orbital, frontal sinus, and anterior skull base anatomy. This rare primary location is undescribed in the pediatric literature.


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