Hypolipidemic and Antioxidant Activities of Corrigiola Telephiifolia in Diabetic Rats.

Morad Hebi, Mohamed Eddouks

Cardiovascular & Hematological Agents in Medicinal Chemistry 2019 Februrary 28

OBJECTIVE: the evaluation of the hypolipidemic and antioxidant activities of the aerial parts aqueous extract of Corrigiola telephiifolia (APAE of C. telephiifolia) in normal and streptozotocin(STZ)-induced diabetic rats.

METHODS: The effects of oral administration of APAE of C. telephiifolia (5 mg/kg) on the lipid profile as well as the in vitro antioxidant activity of this aqueous extract have been determined.

RESULTS: APAE of C. telephiifolia (5 mg/kg) reduced significantly (p<0.001) the plasma total cholesterol levels in diabetic rats. In contrast, no significant increase in plasma triglyceride levels in normal and in STZ-induced diabetic rats. On the other hand, APAE of C. telephiifolia showed an antioxidant activity.

CONCLUSION: the APAE of C. telephiifolia exhibits an antioxidant, cholesterol and body weight-lowering activities in diabetic rats.

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