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JOURNAL ARTICLE

Dual-tracer PET/CT scan after injection of combined [18F]NaF and [18F]FDG outperforms MRI in the detection of myeloma lesions

Nadia Withofs, Yves Beguin, François Cousin, Tino Tancredi, Paolo Simoni, Victoria Alvarez-Miezentseva, Bernard De Prijck, Kaoutar Hafraoui, Christophe Bonnet, Frédéric Baron, Roland Hustinx, Jo Caers
Hematological Oncology 2019 February 28
30821017
The detection rates of whole-body combined [18F]NaF/[18F]FDG PET/CT, CT alone, MRI and X-ray were prospectively studied in patients with treatment-requiring plasma cell disorders The detection rates of imaging techniques were compared and focal lesions were classified according to their anatomic location. Twenty-six out of 30 initially included patients were assessable. The number of focal lesions detected in newly diagnosed patients (n = 13) and in relapsed patients (n = 13) were 296 and 234, respectively. The detection rate of PET/CT was significantly higher than MRI (p < 0.05) and CT (p < 0.0001) both in patients with newly diagnosed and in those with relapsed MM. The X-ray detection rate was significantly lower than all other techniques, while CT detected more lesions compared to MRI at diagnosis (p = 0.025). With regard to the infiltration patters, relapsed patients presented more diffuse patterns, and more focal lesions located in the limbs compared to newly diagnosed patients. In conclusion, the detection rate of [18F]NaF/[18F]FDG PET/CT was significantly higher than CT, MRI and X-ray, while the detection rate of X-rays was significantly lower than all other imaging techniques except for focal lesions located in the skull.

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