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Zeolite-fibrin clot composite as a haemostatic agent for haemophilia A

Xiaoqiang Shang, Yun Long Li, Hao Chen, Lisha Yu, Zhugang Wang, Liping Xiao, Jie Fan
Journal of Biomaterials Applications 2019 February 28, : 885328219832380
Zeolite is a multifunctional material, which recently exhibited promising prospects in emerging biological and medical applications. This study reported a new bio-inorganic hybrid of zeolite-fibrin clot composite serving as haemostatic agent in haemophilia A. The zeolite-fibrin clot composite promoted haemocompatibility and helped to achieve short clotting time both in vitro (22 ± 3 s vs. >600 s) and in vivo (4.5 min vs. >60 min) compared to control in coagulation factor VIII deficiency bleeding model. Therefore, in situations of surgical operation or accidental injury, this effective and ready-to-use haemostatic agent may provide rapid haemostasis for haemophilia A patients.


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