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Autologous nanofat transplantation accelerates foot wound healing in diabetic rats

Li Chen, Zheng-Cai Wang, Jing-Jing Ma, Wen-Jia Sun, Shao-Wen Wang, Zi-Chun Gu, Xuan Yang
Regenerative Medicine 2019, 14 (3): 231-241
Aim: This study explored the effects of local transplantation of autologous nanofat in the treatment of rats with diabetic foot wounds. Materials & methods: Nanofat was transplanted into the left foot wound of diabetic rats. Phosphate-buffered saline injection in the right served as control. We measured wound size, the extent of epithelization, microvessel density and the expression levels of cytokines at six different time-points postoperation. Results: Compared with the control feet, nanofat-treated feet had significantly smaller wound areas at 7 and 9 days after grafting and showed better re-epithelialization, a greater number of microvessels and higher levels of angiogenic factor expression. Conclusion: This research shows that autologous nanofat transplantation can promote diabetic foot wound healing in rats.


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