We have located links that may give you full text access.
Inhibition of Tumor Progression by N G -Nitro-L-arginine Methyl Ester in 7,12- dimethylbenz(a)anthracene Induced Breast Cancer: Nitric Oxide Synthase Inhibition as an Antitumor Prevention.
Journal of Mammary Gland Biology and Neoplasia 2019 Februrary 27
Breast cancer has high mortality rates among the women in the Republic of Armenia. It is now evident that nitric oxide plays important roles in various stages of carcinogenesis such as oncogene activation, tumor suppressor genes, modulation of apoptosis and metastasis. Advances in our understanding of the metabolism and molecular functions of arginine alterations in cancer have led to resurgence in the interest of targeting arginine catabolism, as an anticancer strategy. NOS inhibitors have been proposed, as a way to treat cancer. We have been researching the anti-tumor potential of the NOS inhibition by NG -Nitro-L-arginine methyl ester treatment (30 mg/kg/day, i.p.), administered for 5 weeks (parallelly to tumors development, every 3th day) against 7,12-dimethylbenz(a)anthracene induced mammary carcinogenesis in rats. Our treatment model results have shown the inhibition of NOS activity has influenced on development of carcinogenesis, which have been reflected in changes of rats' tumors size and quantity, mortality rate, in alteration of breast histopathology, in decrease of polyamines, NO and malondialdeide concentrations in blood. Understanding dichotomy of NO has been a great challenge for researchers working in the field of cancer therapy.
Full text links
Trending Papers
A Personalized Approach to the Management of Congestion in Acute Heart Failure.Heart International 2023
Potential Mechanisms of the Protective Effects of the Cardiometabolic Drugs Type-2 Sodium-Glucose Transporter Inhibitors and Glucagon-like Peptide-1 Receptor Agonists in Heart Failure.International Journal of Molecular Sciences 2024 Februrary 21
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app
All material on this website is protected by copyright, Copyright © 1994-2024 by WebMD LLC.
This website also contains material copyrighted by 3rd parties.
By using this service, you agree to our terms of use and privacy policy.
Your Privacy Choices
You can now claim free CME credits for this literature searchClaim now
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app