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Construction of a 6/5/9-membered tricyclic structure of cladiellins via radical-polar crossover reaction.
Journal of Antibiotics 2019 Februrary 26
A three-component coupling reaction of structurally simple 6-8 was successfully applied for expeditious synthesis of the 6/5/9-membered tricyclic structure 3 of cladieunicellin D (1) and klysimplexin U (2). Upon treatment with the Et3 B/O2 reagent system, α-alkoxyacyl telluride 6, six-membered enone 7, and (Z)-4-hexenal (8) were linked in one pot to provide the densely functionalized 5 via sequential decarbonylative radical generation, radical addition, boron enolate formation, and intermolecular aldol reaction. Subsequent Lewis acid-promoted reductive etherification and SiO2 -induced C10-epimerization gave rise to the cis-fused five-membered ether of 4. Finally, cyclization of the nine-membered ring was achieved by the ring-closing metathesis reaction, giving rise to 3. Compound 3 possesses the six stereocenters of 1 and 2, and would thus serve as an advanced intermediate for their total syntheses.
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