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Human-relevant preclinical in vitro models for studying hepatobiliary development and liver diseases using induced pluripotent stem cells.

Pooja Chaudhari, Lipeng Tian, Zhaohui Ye, Yoon-Young Jang
Experimental Biology and Medicine 2019 Februrary 27
IMPACT STATEMENT: In this review, we address the potential of human-induced pluripotent stem cell-based hepatobiliary differentiation technology as a means to study human liver development and cell fate determination, and to model liver diseases in an effort to develop a new human-relevant preclinical platform for drug development.

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