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Short-Term Changes in Cardiac Function in Osteosarcoma Patients Receiving Anthracyclines.
Journal of Adolescent and Young Adult Oncology 2019 Februrary 23
Studies of cardiac function in adolescent and young adult survivors have been performed at least a decade after anthracycline exposure, with little knowledge of short-term changes in cardiac function in this age group. To this end, we evaluated cardiac function within a 2-year period among 18 patients who received high-dose anthracyclines for osteosarcoma treatment. At 2 years, there was a significant decline in left ventricular ejection fraction (p = 0.005), with 8 of 18 patients having a >10% reduction. There was a significant change in E-wave velocity (p = 0.04). To our knowledge, this is the first study assessing short-term change in systolic and diastolic function in osteosarcoma patients receiving anthracyclines.
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