Argyrophilic grain disease: a clinicopathological review of an overlooked tauopathy

Sumit Das, Abdullah Ishaque
Folia Neuropathologica 2018, 56 (4): 277-283
Argyrophilic grain disease (AGD) is a sporadic tauopathy and actually the second most frequent cause of dementia after Alzheimer's disease. Patients can present with slowly progressive cognitive decline as well as psychiatric manifestations such as depression. Definite diagnosis of AGD can only be made by post-mortem examination of the brain. Neuropathological features include argyrophilic grains in limbic areas along with oligodendroglial coiled bodies in hippocampal and amygdaloid white matter, and ballooned neurons in the amygdala. AGD, however, can often be overlooked and missed on neuropathologic examination as there are actually no specific clinical manifestations that would be considered highly suggestive of AGD. Thus, it is not uncommon to find neuropathological features of AGD in patients who do not present with any apparent neurological manifestations. The aim of this review is to provide an overview of what is currently known about AGD as well as raise its awareness among both neurologists and neuropathologists who may otherwise overlook this interesting tauopathy. We believe that patients above the age of 60 years should undergo post-mortem screening for AGD to avoid missed opportunity for diagnosis and enable future clinicopathological studies.

Full Text Links

Find Full Text Links for this Article


You are not logged in. Sign Up or Log In to join the discussion.

Trending Papers

Available on the App Store

Available on the Play Store
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"