Differentially expressed coding and noncoding RNAs in CoCl 2 -induced cytotoxicity of C2C12 cells.

Rui Chen, Yanling She, Qiang Fu, Xiaodan Chen, Huacai Shi, Si Lei, Shanyao Zhou, Jun Ou, Yulin Liu

Epigenomics 2019 Februrary 21

AIM: We aimed to explore potential regulators of coding and noncoding RNAs (ncRNAs) in Co(II) ion-induced myo cytotoxicity.

MATERIALS & METHODS: We confirmed the toxic effects of Co(II) on mouse skeletal C2C12 myotubes by CoCl2 , and performed the expression profiles of circular RNAs (circRNAs), long noncoding RNAs (lncRNAs) and mRNAs using microarray analysis. We constructed co-expression, competing endogenous RNA and cis/trans regulation networks for ncRNAs, and filtered 71 candidate circRNAs with coding potential.

RESULTS: We identify 605 differentially expressed circRNAs, 4409 long noncoding RNAs and 3965 mRNAs. We also provided several ncRNAs regulation networks and presumed functions of circRNAs with coding potential.

CONCLUSION: Our findings may reveal novel regulatory mechanisms underlying the noxious effects of CoCl2 in skeletal muscle.

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