A new approach to estimate ultrafine particle respiratory deposition

Wei-Chung Su, Yi Chen, Jinxiang Xi
Inhalation Toxicology 2019 February 20, : 1-9
Ultrafine particles (UFPs) in workplaces have been and continue to be an important occupational health concern. The inhalation and the consequent deposition of UFPs in workers' lower airways can lead to many adverse health effects. Therefore, it is vital to study the deposition of UFPs in the human respiratory tract from the viewpoint of occupational health. In this study, a set of physiologically representative human tracheobronchial airway replicas were made using high-resolution 3D printers, and a new approach that was distinct from the traditional methods was developed to apply these airway replicas in estimating UFP respiratory deposition. The results showed that UFP respiratory deposition could be readily and systematically measured by the differential-based approach. The results of this study imply the feasibility of developing a mobile aerosol lung deposition apparatus in the future for on-site workplace UFP respiratory deposition to evaluate the UFP inhalation dosimetry for workers in the real workplaces.

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