The Terminalia Laxiflora Modulates The Neurotoxicity Induced By Fipronil In Male Albino Rats.

The extensive use of fipronil (FPN) may trigger hazards to more than insects. The present investigation was carried out to evaluate the abrogating role of Terminalia laxiflora methanol extract against the neurotoxic effects provoked by FPN. Fourty male albino rats rats were assigned into four equal groups. The first group served as control, the second one was orally administered with FPN (10.5mg/kg BW), the third group was given combination of FPN and T.laxiflora methanol extract (TLE) (100 mg/kg BW) and the fourth one was orally given TLE. Our  findings highlighted the efficacy of TLE as a neuro-protectant through a significant reduction of MDA content by 25.8%,  elevations of the GSH level, CAT  and SOD activities by 30.9%,  41.2% and 48.2% respectively.Consequently, the relative m-RNA levels of both Bax and caspase-3 were down regulated 40.54 % and caspase-3 by 30.35% compared to the control group. Moreover, restoration of the pathological tissue injuries were detected. In conclusion, TLE is proved to be a potent neuro-protective agent against the fipronil induces toxicity.