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OPN gene locus is associated with the risk of knee osteoarthritis: a case-control study.

Bioscience Reports 2019 Februrary 19
BACKGROUND/AIMS: Studies have demonstrated that osteopontin (OPN) was associated with the severity and development of knee osteoarthritis (OA).

METHODS: The purpose of this case-control study was to investigate the association between OPN gene rs11730582 polymorphism and knee OA risk in a Chinese population. Genotyping was analyzed using standard polymerase chain reaction and restriction fragment length polymorphism (PCR-RFLP).

RESULTS: This study found that C allele or CC genotype of OPN gene rs11730582 polymorphism was related to decreased risk for knee OA. Furthermore, positive associations were obtained among the female, and BMI <25 kg/m2 groups.

CONCLUSIONS: To sum up, this study reveals that OPN gene rs11730582 polymorphism decreases the risk of knee OA in Chinese Han population.

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