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Evaluation of novel N '-(3-hydroxybenzoyl)-2-oxo-2 H -chromene-3-carbohydrazide derivatives as potential HIV-1 integrase inhibitors.
MedChemComm 2019 January 2
In an attempt to identify potential new agents that are active against HIV-1 IN, a series of novel coumarin-3-carbohydrazide derivatives were designed and synthesised. The toxicity profiles of these compounds showed that they were non-toxic to human cells and they exhibited promising anti-HIV-1 IN activities with IC50 values in nM range. Also, an accompanying molecular modeling study showed that the compounds bind to the active pocket of the enzyme.
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