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The effect of two doses of fentanyl on chest wall rigidity at equipotent doses of isoflurane in dogs.

OBJECTIVE: To evaluate the effect of two doses of fentanyl upon chest wall rigidity of dogs anesthetized at equipotent doses of isoflurane [1.3 minimum alveolar concentration (MACISO ) of each dose of fentanyl].

STUDY DESIGN: Prospective crossover randomized study.

ANIMALS: A group of eight male Beagle dogs, approximately 1 year old and weighing 12.1 ± 1.6 kg (mean ± standard deviation).

METHODS: The dogs were anesthetized with isoflurane and instrumented for the measurement of esophageal pressure (PESO ), flow (V˙) and volume (V). Chest wall elastance (ECW ) was estimated by multiple linear regression of the model. PESO (t) = V˙(t) × RCW  + V(t) × ECW  + EEPESO where t is time, RCW is chest wall resistance and EEPESO is end-expiratory PESO . Chest wall compliance (CCW ) was calculated as 1/ECW and normalized to the body weight of each dog (mL cmH2 O-1 kg-1 ). Anesthesia was maintained at 1.3 MACISO for at least 15 minutes and CCW recorded (CCW-ISO ). The dogs were randomly assigned to the lower fentanyl dose [loading dose (33 μg kg-1 ) and infusion (0.2 μg kg-1 minute-1 )] or the higher fentanyl dose [loading dose (102 μg kg-1 ) and infusion (0.8 μg kg-1 minute-1 )]. After 60 minutes of fentanyl infusion, CCW was recorded for each dose (CCW-FENT ). During fentanyl infusion, the dogs were maintained at equipotent doses of isoflurane (1.3 MACISO for each fentanyl dose). A two-way analysis of variance followed by a Bonferroni test was used to compare CCW-ISO and CCW-FENT in both treatments and CCW-FENT between treatments. A p value <0.05 was considered significant.

RESULTS: Neither of the fentanyl doses decreased CCW and there was no difference in CCW-FENT between doses.

CONCLUSIONS AND CLINICAL RELEVANCE: Fentanyl at the studied doses did not result in chest wall rigidity in dogs anesthetized with equipotent doses of isoflurane (1.3 MACISO ).

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