Altered dynamic global signal topography in antipsychotic-naive adolescents with early-onset schizophrenia.

Schizophrenia (SCZ) is a severe neuropsychiatric disease associated with dysfunction of brain regions and networks. Recent, functional magnetic resonance imaging (fMRI) studies have determined that the global signal (GS) is an important source of the local neuronal activity. However, the dynamics of this effect in SCZ remains unknown. To address this issue, 39 drug-naive patients with early-onset schizophrenia (EOS) and 31 age-, gender- and education-matched healthy controls underwent resting-state fMRI scans. Dynamic functional connectivity (DFC) was employed to assess the dynamic patterns of the GS in EOS. Dynamic analysis demonstrated that the topography of the GS in EOS can be divided into five different states. In the state1, the GS mainly affected the sensory regions. In the state2, the GS mainly affected the default mode network (DMN). In the state3, the GS mainly affected the frontoparietal network and the cingulate-opercular network. In the state4, the GS mainly affected the sensory and subcortical regions. In the state5, the GS mainly affected the sensory regions and DMN. In particular, the changes in the cerebellum, putamen and supramarginal gyrus was inversely proportional to the clinical symptoms. Our findings demonstrate that the influence of the GS on brain networks is dynamic and changes of this relationship may associate with clinical behavior in SCZ.