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A randomized controlled trial comparing crude versus heparin-bonded PRFE graft in below the knee bypass surgery for critical limb ischemia (REPLACE trial). Design and protocol.

Annals of Vascular Surgery 2019 Februrary 13
BACKGROUND: While autogenous venous graft is preferable in below the knee bypass surgery for patients in critical limb ischemia, some 20% of patients will have no suitable vein for grafting, compelling a resort to artificial graft materials. Retrospective sub-group analyses within published studies comparing heparin-bonded PTFE with crude PFTE graft in below the knee bypass suggest that heparin-bonded graft offers superior long-term patency rates, but this has not been prospectively verified in patients with critical limb ischemia.

RESEARCH QUESTION: Is heparin-bonded PTFE graft superior to crude PTFE graft in below the knee bypass surgery for critical limb ischemia?

SETTING: Twenty vascular surgery departments in university hospitals in France.

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