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An Ultrasensitive Electrochemiluminescent Sensor for MicroRNA with Multinary Zn-Ag-In-S/ZnS Nanocrystals as Tags.

Analytical Chemistry 2019 Februrary 15
To screen novel toxic-element-free and biocompatible electrochemiluminophores, electrochemluminescence (ECL) of mul-tinary nanocrystals (NCs) was investigated for the first time with Zn-Ag-In-S (ZAIS) NCs as model. Aqueous soluble ZAIS NCs could bring out efficient reductive-oxidation ECL with tri-n-propylamine as co-reactant, while coating the ZAIS NCs with a ZnS shell could reduce the surface defects of ZAIS NCs, and enable 6.7 folds enhanced ECL of ZAIS/ZnS NCs than ZAIS NCs. ECL of ZAIS/ZnS NCs was about 4.2 folds to that of ternary CuInS2 /ZnS NCs, spectrally similar to that of Ru(bpy)3 2+ with maximum emission around 605 nm, and favorable for less electrochemical interference with a lowered triggering potential (~0.95 V) than that of Ru(bpy)3 2+ . An ultrasensitive ECL microRNA sensor was fabricated with ZAIS/ZnS NCs as tags, which could sensitively and selectively determine microRNA-141 with a wide linearity range from 0.1 fmol/L to 20 pmol/L and a low limit of detection at 50 amol/L (S/N = 3). Multinary NCs might provide a promising alternative to the traditional binary NCs for both electrochemiluminophore screening and NCs ECL modulating.

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