Ultrastructural analysis of the Krebs-2 ascites cancer cells treated with extracellular double-stranded DNA preparation

Svetlana S Kirikovich, Oleg S Taranov, Vladimir V Omigov, Ekaterina A Potter, Evgenia V Dolgova, Anastasia S Proskurina, Yaroslav R Efremov, Sergey S Bogachev
Ultrastructural Pathology 2019 February 13, : 1-10
Electron-microscopic analysis of the ultrastructure of the Krebs-2 carcinoma ascites cells in the first 90 min immediately after their exposure to fragmented double-stranded DNA has been performed. Morphological attributes of the treated cancer cells indicate the induction in these cells of destructive processes of presumably apoptotic type. The predominance of dystrophic-destructive changes in cells after the addition of DNA is supposed to be a consequence of the disturbance in metabolic processes caused by the experimental action.

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