We have located links that may give you full text access.
A Phosphinate-Containing Fluorophore Capable of Selectively Inducing Apoptosis in Cancer Cells.
Chembiochem : a European Journal of Chemical Biology 2019 Februrary 13
Chemotherapeutic agents generally suffer from off-target cytotoxicity in noncancerous cell types, leading to undesired side effects. As a result, significant effort has been put into identifying compounds that are selective for cancerous versus noncancerous cell types. Our lab has recently developed a series of near-infrared (NIR) fluorophores containing a phosphinate functionality at the bridging position of the xanthene scaffold, termed Nebraska Red (NR) fluorophores. Herein, we report the selective cytotoxicity of one NR derivative, NR744, against HeLa (cervical cancer) cells versus NIH-3T3 (noncancerous fibroblast) cells. Mechanistic studies, utilizing the NIR fluorescence signal afforded by NR744, showed distinct subcellular localization in HeLa (mitochondrial) versus NIH-3T3 (lysosomal), resulting from the elevated mitochondrial potential in HeLa cells. This study provides a new, NIR scaffold for the further development of reagents for targeted cancer therapy.
Full text links
Related Resources
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app
All material on this website is protected by copyright, Copyright © 1994-2024 by WebMD LLC.
This website also contains material copyrighted by 3rd parties.
By using this service, you agree to our terms of use and privacy policy.
Your Privacy Choices
You can now claim free CME credits for this literature searchClaim now
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app