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A novel nanoformulation of α-eleostearic acid restores molecular pathogenesis of hypersensitivity.
Nanomedicine 2019 Februrary 13
AIM: The present work provides first-time empirical and molecular interaction evidence to establish the higher biofunctionality of a therapeutic lipid, α-eleostearic acid (ESA), encapsulated in a novel and thoroughly characterized biocompatible nanoemulsion (NE) system (particle size <200 nm).
MATERIALS & METHODS: A novel methodology was employed to fabricate novel formulations of ESA. Molecular biological tools and assays were used to arrive at definite conclusions.
RESULTS: The proinflammatory profile was found to be significantly mitigated in the hypersensitized rats administered with the ESA-NE formulation more emphatically as compared with ESA-conventional emulsion in both in vivo and ex vivo models.
CONCLUSION: The novel ESA-NE formulation shows a lot of palpable promise for clinical applications.
MATERIALS & METHODS: A novel methodology was employed to fabricate novel formulations of ESA. Molecular biological tools and assays were used to arrive at definite conclusions.
RESULTS: The proinflammatory profile was found to be significantly mitigated in the hypersensitized rats administered with the ESA-NE formulation more emphatically as compared with ESA-conventional emulsion in both in vivo and ex vivo models.
CONCLUSION: The novel ESA-NE formulation shows a lot of palpable promise for clinical applications.
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