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Common Variable Immunodeficiency: Epidemiology, Pathogenesis, Clinical manifestations, Diagnosis, Classification and Management

R Yazdani, S Habibi, L Sharifi, G Azizi, H Abolhassani, P Olbrich, A Aghamohammadi
Journal of Investigational Allergology & Clinical Immunology 2019 February 11
Common variable immunodeficiency (CVID) is a heterogeneous disorder characterized by hypogammaglobulinemia and increased susceptibility to recurrent bacterial infections. It is the most frequent symptomatic antibody deficiency with a wide variety of infectious and non-infectious complications. Numerous studies demonstrated that different immunological and genetic defects are involved in the pathogenesis of CVID. However, in most cases, the genetic background of the disease remains unidentified. This review aims to discuss different aspects of CVID including epidemiology, pathogenesis, symptoms, diagnosis, classifications and management of the disease.


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