We have located links that may give you full text access.
Different phenotypes of CD4 + CD25 + Foxp3 + regulatory T cells in recipients post liver transplantation.
International Immunopharmacology 2019 Februrary 6
CD4+ regulatory T cells (Tregs) play an important role in inducing immune tolerance in organ transplantation, which can be divided into CD45RA+ Tregs (resting Tregs, rTregs) and CD45RO+ Tregs (activated Tregs, aTregs). Currently, the expressions and phenotypic changes of Tregs in recipients after liver transplantation (LT) is unknown. We therefore investigated the expression and transformation of rTregs and aTregs in 83 cases of recipients with normal status post-LT. The percentages of CD45RA, CD45RO, CD31 in CD4+ Tregs were detected by flow cytometry and the effective factors were analyzed. In LT recipients, the percentage of CD45RO+ Tregs in CD4+ Tregs was higher than that of CD45RA+ Tregs. There was significant difference in the ratio of positive Foxp3 between CD45RA+ Tregs and CD45RO+ Tregs. Percentage of CD45RA+ Tregs was higher in pediatric group than that in adult group, whereas percentage of CD45RO+ Tregs was lower in the pediatric group. However, it was different only in CD45RO+ Tregs in various survival periods post-LT. In conclusion, Tregs pool in human was heterogeneous post-LT and contained different subsets in phenotypes. Upon stimulation by donor graft, percentages of CD4+ Tregs and CD45RO+ Tregs were increased post-LT and most of rTregs was transformed into aTregs in peripheral blood, and rTregs and aTregs were both related to recipients' ages.
Full text links
Related Resources
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app
All material on this website is protected by copyright, Copyright © 1994-2024 by WebMD LLC.
This website also contains material copyrighted by 3rd parties.
By using this service, you agree to our terms of use and privacy policy.
Your Privacy Choices
You can now claim free CME credits for this literature searchClaim now
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app