We have located links that may give you full text access.
Evaluating mucoadhesion properties of three types of nanocellulose in the gastrointestinal tract in vitro and ex vivo.
Carbohydrate Polymers 2019 April 16
The mucoadhesive properties of three types of nanocellulose (CNF, CNC, and Tempo-CNF) was investigated in the digestive condition with ex vivo and in vitro assays. In the ex vivo flow-through method, three nanocellulose materials showed different levels of retention on porcine gastric and intestinal mucosal surfaces. Fluorescence microscopy confirmed that retention of CNF could be due to entanglement with the mucosal layer, while retention of Tempo-CNF could be due to instantaneous gelling on the mucosal surface. In an in vitro viscometric method, 2% CNC showed the highest viscosity synergism (relative enhancement=11.80 ± 1.14) in the gastric condition, while Tempo-CNF only displayed synergism under gelling concentrations (0.1%). Evaluation of zeta potential revealed that 0.025-0.1% CNC interacted with mucin particles by changing the surface charge of the mucin-nanocellulose system. These results indicate that nanocellulose shows mucoadhesive properties in digestive tract, where the level of adhesion depends on type of nanocellulose, its concentration and the gastrointestinal section.
Full text links
Related Resources
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app
All material on this website is protected by copyright, Copyright © 1994-2024 by WebMD LLC.
This website also contains material copyrighted by 3rd parties.
By using this service, you agree to our terms of use and privacy policy.
Your Privacy Choices
You can now claim free CME credits for this literature searchClaim now
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app