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The Effect of Voluntary Fasting and Dehydration on Posterior Ocular Structures.
Cutaneous and Ocular Toxicology 2019 Februrary 7
PURPOSE: Islamic Ramadan is the month of fasting, in which intake of food and drink is restricted from sunrise until sunset. The objective of the present study was to find out the effects of religious fasting on posterior ocular structures.
MATERIALS AND METHODS: In this prospective study, 34 eyes of 34 healthy volunteers with a mean age of 34.09 ± 7.20 years were enrolled. Volunteers with any systemic disorder and eyes with pathology or previous surgery were excluded. One week before Ramadan (non-fasting period) and during Ramadan (fasting period) at the same hours (at 08:00 and 16:00 hours), choroidal, macular and retinal nerve fiber layer thicknesses were measured by spectral domain optical coherence tomography. Results were compared using paired sample t test, and a p value less than 0.05 was accepted as statistically significant.
RESULTS: The comparison of 16:00-hour measurements revealed significantly lower values during fasting period when compared non-fasting period for choroidal thickness (non-fasting and fasting, respectively; subfoveal: 299.26 ± 41.3 and 280.03 ± 38.75 p < 0.001, nasal: 246.09 ± 53.59 and 227.06 ± 53.82 p < 0.001, and temporal: 273.56 ± 42.68 and 257.44 ± 45.06 p=0.001) and paracentral macular thickness (superior: p=0.002, inferior: p=0.010, temporal: p=0.013, and nasal: p=0.016). By contrast, no significant differences were found in the central macular thickness between the fasting and non-fasting periods (p = 0.735). Also, no statistically significant difference was noted for retinal nerve fiber layer thickness at the different periods and time points.
CONCLUSION: Our results reveal that Islamic religious fasting is associated with statistically significant alterations in choroidal and paracentral macular thickness in healthy volunteers. However, more detailed investigations should be designed to evaluate whether fasting has a pivotal influence on pathological conditions.
MATERIALS AND METHODS: In this prospective study, 34 eyes of 34 healthy volunteers with a mean age of 34.09 ± 7.20 years were enrolled. Volunteers with any systemic disorder and eyes with pathology or previous surgery were excluded. One week before Ramadan (non-fasting period) and during Ramadan (fasting period) at the same hours (at 08:00 and 16:00 hours), choroidal, macular and retinal nerve fiber layer thicknesses were measured by spectral domain optical coherence tomography. Results were compared using paired sample t test, and a p value less than 0.05 was accepted as statistically significant.
RESULTS: The comparison of 16:00-hour measurements revealed significantly lower values during fasting period when compared non-fasting period for choroidal thickness (non-fasting and fasting, respectively; subfoveal: 299.26 ± 41.3 and 280.03 ± 38.75 p < 0.001, nasal: 246.09 ± 53.59 and 227.06 ± 53.82 p < 0.001, and temporal: 273.56 ± 42.68 and 257.44 ± 45.06 p=0.001) and paracentral macular thickness (superior: p=0.002, inferior: p=0.010, temporal: p=0.013, and nasal: p=0.016). By contrast, no significant differences were found in the central macular thickness between the fasting and non-fasting periods (p = 0.735). Also, no statistically significant difference was noted for retinal nerve fiber layer thickness at the different periods and time points.
CONCLUSION: Our results reveal that Islamic religious fasting is associated with statistically significant alterations in choroidal and paracentral macular thickness in healthy volunteers. However, more detailed investigations should be designed to evaluate whether fasting has a pivotal influence on pathological conditions.
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