We have located links that may give you full text access.
Journal Article
Review
The review of differential equation models of HBV infection dynamics.
Journal of Virological Methods 2019 Februrary 2
Understanding the infection and pathogenesis mechanism of hepatitis B virus (HBV) is very important for the prevention and treatment of hepatitis B. Mathematical models contribute to illuminate the dynamic process of HBV replication in vivo. Therefore, in this paper we review the viral dynamics in HBV infection, which may help us further understand the dynamic mechanism of HBV infection and efficacy of antiviral treatment. Firstly, we introduce a family of deterministic models by considering different biological mechanisms, such as, antiviral therapy, CTL immune response, multi-types of infected hepatocytes, time delay and spatial diffusion. Particularly, we briefly describe the stochastic models of HBV infection. Secondly, we introduce the commonly used parameter estimation methods for HBV viral dynamic models and briefly discuss how to use these methods to estimate unknown parameters (such as drug efficacy) through two specific examples. We also discuss the idea and method of model identification and use a specific example to illustrate its application. Finally, we propose three new research programs, namely, considering HBV drug-resistant strain, coupling within-host and between-host dynamics in HBV infection and linking population dynamics with evolutionary dynamics of HBV diversity.
Full text links
Related Resources
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app
All material on this website is protected by copyright, Copyright © 1994-2024 by WebMD LLC.
This website also contains material copyrighted by 3rd parties.
By using this service, you agree to our terms of use and privacy policy.
Your Privacy Choices
You can now claim free CME credits for this literature searchClaim now
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app