We have located links that may give you full text access.
JOURNAL ARTICLE
REVIEW
Activation Mechanisms and Multifaceted Effects of Mast Cells in Ischemia Reperfusion Injury.
Experimental Cell Research 2019 Februrary 2
Mast cells (MCs) are tissue resident effector cells that form an important part of the immune system's first-line of defence against various pathogenic challenges. They are well known for their roles in anaphylaxis and allergy; however, increasing evidence implicates MCs in a wide range of pathologies. Ischemia/reperfusion (I/R) injury elicits an inflammatory response and triggers the program of tissue damage and restoration, as well as immune regulation. MCs are uniquely distributed around microvasculature and potentially the first responders to early or specific aspects of IR pathogenesis through the release of preformed mediators of MC granule. Versatility and extreme heterogeneity are hallmarks of MCs, resulting from different adaptions acquired during phylogenesis; such plasticity is also highlighted during MC development. Thus, it is necessary to discuss the functions of the MC population that could differ depending on the tissue in which they reside, and various effects of MCs can be induced by stimuli during I/R. In this review, we primarily discuss the contribution of MC activation in I/R injuries of hepatic, pulmonary, myocardial, cerebral, renal, and intestinal organs or systems. A further understanding of the mechanisms underlying the role of MCs in I/R injuries would aid the development of specific MC-targeted therapeutics to protect against some specific injury, such as negating the proinflammatory roles of some specific MC mediators.
Full text links
Related Resources
Trending Papers
Heart failure with preserved ejection fraction: diagnosis, risk assessment, and treatment.Clinical Research in Cardiology : Official Journal of the German Cardiac Society 2024 April 12
Proximal versus distal diuretics in congestive heart failure.Nephrology, Dialysis, Transplantation 2024 Februrary 30
Efficacy and safety of pharmacotherapy in chronic insomnia: A review of clinical guidelines and case reports.Mental Health Clinician 2023 October
World Health Organization and International Consensus Classification of eosinophilic disorders: 2024 update on diagnosis, risk stratification, and management.American Journal of Hematology 2024 March 30
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app
All material on this website is protected by copyright, Copyright © 1994-2024 by WebMD LLC.
This website also contains material copyrighted by 3rd parties.
By using this service, you agree to our terms of use and privacy policy.
Your Privacy Choices
You can now claim free CME credits for this literature searchClaim now
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app