We have located links that may give you full text access.
JC viruria associates with reduced risk of diabetic kidney disease.
Journal of Clinical Endocrinology and Metabolism 2019 January 31
Purpose: African Americans who shed JC polyoma virus (JCV) in their urine have reduced rates of non-diabetic chronic kidney disease (CKD). The present study assessed associations between urinary JCV and urine BK polyomavirus (BKV) with CKD in African Americans with diabetes mellitus.
Methods: African Americans with diabetic kidney disease and controls lacking nephropathy from the Family Investigation of Nephropathy and Diabetes Consortium (FIND) and African American-Diabetes Heart Study (AA-DHS) had urine tested for JCV and BKV using quantitative polymerase chain reaction. Among 335 individuals tested, 148 were cases with diabetic kidney disease and 187 were controls.
Results: JCV viruria was detected more often in controls than in cases with diabetic kidney disease, respectively (FIND: 46.6% vs. 32.2%, odds ratio [OR] 0.52, 95% confidence interval [CI] 0.29-0.93; p=0.03; AA-DHS: 30.4% vs. 26.2%, OR 0.63, 95% CI 0.27-1.48; p=0.29). A joint-analysis adjusting for age, gender and study revealed that JC viruria was inversely associated with diabetic kidney disease (OR 0.56, 95% CI 0.35-0.91; p=0.02). Significant relationships between BKV and diabetic kidney disease were not observed.
Main Conclusions: This study extends the inverse association between urine JCV and non-diabetic nephropathy in African Americans to diabetic kidney disease. Results imply that common pathways likely involving the innate immune system mediate coincident chronic kidney injury along with restriction of JCV replication. Future studies are needed to explore causative pathways and characterize whether absence of JC viruria can serve as a biomarker for diabetic kidney disease in the African American population.
Methods: African Americans with diabetic kidney disease and controls lacking nephropathy from the Family Investigation of Nephropathy and Diabetes Consortium (FIND) and African American-Diabetes Heart Study (AA-DHS) had urine tested for JCV and BKV using quantitative polymerase chain reaction. Among 335 individuals tested, 148 were cases with diabetic kidney disease and 187 were controls.
Results: JCV viruria was detected more often in controls than in cases with diabetic kidney disease, respectively (FIND: 46.6% vs. 32.2%, odds ratio [OR] 0.52, 95% confidence interval [CI] 0.29-0.93; p=0.03; AA-DHS: 30.4% vs. 26.2%, OR 0.63, 95% CI 0.27-1.48; p=0.29). A joint-analysis adjusting for age, gender and study revealed that JC viruria was inversely associated with diabetic kidney disease (OR 0.56, 95% CI 0.35-0.91; p=0.02). Significant relationships between BKV and diabetic kidney disease were not observed.
Main Conclusions: This study extends the inverse association between urine JCV and non-diabetic nephropathy in African Americans to diabetic kidney disease. Results imply that common pathways likely involving the innate immune system mediate coincident chronic kidney injury along with restriction of JCV replication. Future studies are needed to explore causative pathways and characterize whether absence of JC viruria can serve as a biomarker for diabetic kidney disease in the African American population.
Full text links
Trending Papers
A Personalized Approach to the Management of Congestion in Acute Heart Failure.Heart International 2023
Potential Mechanisms of the Protective Effects of the Cardiometabolic Drugs Type-2 Sodium-Glucose Transporter Inhibitors and Glucagon-like Peptide-1 Receptor Agonists in Heart Failure.International Journal of Molecular Sciences 2024 Februrary 21
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app
All material on this website is protected by copyright, Copyright © 1994-2024 by WebMD LLC.
This website also contains material copyrighted by 3rd parties.
By using this service, you agree to our terms of use and privacy policy.
Your Privacy Choices
You can now claim free CME credits for this literature searchClaim now
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app