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Thin Skinned: Aged Adipocyte Atrophy Impacts Innate Immunity.
Trends in Immunology 2019 January 32
In a recent study, Zhang et al. (Immunity 2019;50:121-136) report that adipocyte atrophy in aged skin increases susceptibility to bacterial infection. Enhanced TGF-β signaling in aged adipocyte progenitor cells induces a fibrotic cell fate that lacks antimicrobial peptides produced by mature adipocytes, highlighting the importance of stromal cells as innate immune effectors.
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