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Machine Learning-based Analysis of Rectal Cancer MRI Radiomics for Prediction of Metachronous Liver Metastasis.
Academic Radiology 2019 November
RATIONALE AND OBJECTIVES: To use machine learning-based magnetic resonance imaging radiomics to predict metachronous liver metastases (MLM) in patients with rectal cancer.
MATERIALS AND METHODS: This study retrospectively analyzed 108 patients with rectal cancer (54 in MLM group and 54 in nonmetastases group). Feature selection were performed in the radiomic feature sets extracted from images of T2-weighted image (T2WI) and venous phase (VP) sequence respectively, and the combining feature set with 2058 radiomic features incorporating two sequences with the least absolute shrinkage and selection operator method. Five-fold cross-validation and two machine learning algorithms (support vector machine [SVM]; logistic regression [LR]) were utilized for predictive model constructing. The diagnostic performance of the models was evaluated by receiver operating characteristic curves with indicators of accuracy, sensitivity, specificity and area under the curve, and compared by DeLong test.
RESULTS: Five, 8, and 22 optimal features were selected from 1029 T2WI, 1029 VP, and 2058 combining features, respectively. Four-group models were constructed using the five T2WI features (ModelT2 ), the 8 VP features (ModelVP ), the combined 13 optimal features (Modelcombined ), and the 22 optimal features selected from 2058 features (Modeloptimal ). In ModelVP , the LR was superior to the SVM algorithm (P = 0.0303). The Modeloptimal using LR algorithm showed the best prediction performance (P = 0.0019-0.0081) with accuracy, sensitivity, specificity, and area under the curve of 0.80, 0.83, 0.76, and 0.87, respectively.
CONCLUSION: Radiomics models based on baseline rectal magnetic resonance imaging has high potential for MLM prediction, especially the Modeloptimal using LR algorithm. Moreover, except for ModelVP , the LR was not superior to the SVM algorithm for model construction.
MATERIALS AND METHODS: This study retrospectively analyzed 108 patients with rectal cancer (54 in MLM group and 54 in nonmetastases group). Feature selection were performed in the radiomic feature sets extracted from images of T2-weighted image (T2WI) and venous phase (VP) sequence respectively, and the combining feature set with 2058 radiomic features incorporating two sequences with the least absolute shrinkage and selection operator method. Five-fold cross-validation and two machine learning algorithms (support vector machine [SVM]; logistic regression [LR]) were utilized for predictive model constructing. The diagnostic performance of the models was evaluated by receiver operating characteristic curves with indicators of accuracy, sensitivity, specificity and area under the curve, and compared by DeLong test.
RESULTS: Five, 8, and 22 optimal features were selected from 1029 T2WI, 1029 VP, and 2058 combining features, respectively. Four-group models were constructed using the five T2WI features (ModelT2 ), the 8 VP features (ModelVP ), the combined 13 optimal features (Modelcombined ), and the 22 optimal features selected from 2058 features (Modeloptimal ). In ModelVP , the LR was superior to the SVM algorithm (P = 0.0303). The Modeloptimal using LR algorithm showed the best prediction performance (P = 0.0019-0.0081) with accuracy, sensitivity, specificity, and area under the curve of 0.80, 0.83, 0.76, and 0.87, respectively.
CONCLUSION: Radiomics models based on baseline rectal magnetic resonance imaging has high potential for MLM prediction, especially the Modeloptimal using LR algorithm. Moreover, except for ModelVP , the LR was not superior to the SVM algorithm for model construction.
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