JOURNAL ARTICLE
RESEARCH SUPPORT, NON-U.S. GOV'T
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Changes of γδT cell subtypes during pregnancy and their influences in spontaneous abortion.

A successful pregnancy is a complicated process that involves the precisely timed regulation of endocrine as well as immune system. Despite increasing knowledge about immunology in gestation, the studies of immune cells in endometrium and decidua are still fragmented. Dynamic data is lacking on the transition of pre-pregnancy endometrial lymphocytes to initial pregnancy states as well as to second/third-trimester status. Here, we determined the composition of Gamma delta (γδ) T cells in endometrium and decidua from women with normal pregnancy and unexplained spontaneous abortion. We found that the frequency of γδT cells is fluctuating over the course of pregnancy, and these changes were regulated by progesterone. Different from peripheral blood, Vδ1+ γδT cells accounted for the majority in endometrium and early-pregnancy decidua of healthy women, and endometrial stromal cells (ESCs) may involve in Vδ1/ Vδ2 shift directly. Moreover, an increase in the percentage of γδT cells with Vδ2 subset predominant in early-pregnancy decidua was associated with unexplained spontaneous abortion. Our results unraveled the precise timing of γδT cells occurring during pregnancy and the close relationship among endocrine, immune cells and pregnancy, which can further help understand and solve the problem of infertility and unexplained spontaneous abortion.

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