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Involvement of M1 and M3 receptors in isolated pancreatic islets function during weight cycling in ovariectomized rats.
Biochemistry and Cell Biology 2019 Februrary 2
We investigate structural and functional adaptations of the pancreas during weight cycling in animals submitted to hypoestrogenism. Female Wistar groups: ShamAL (AL: ad libitum), OVXAL (ovariectomized), and OVXcycle (dietary restriction with weight cycling). The ShamAL and OVXAL received ad libitum commercial feed, while the OVXcycle received 21 days of ad libitum commercial feed and 21 days of caloric restriction with 40% of the amount of feed consumed by the OVXAL. The tolerance tests for glucose and insulin were applied. After euthanasia, the pancreas and adipose tissue were collected. A higher rate of disappearance of glucose during the insulin assay was observed for the OVXcycle, compared to the OVXAL. Fasting glycemia and perirenal adipose tissue were lower for the OVXcycle. In comparison with the ShamAL and OVXAL, the OVXcycle showed higher protein expression of the M1 and M3 receptors, SOD1-2 as well as higher carbachol-induced insulin secretion. Under highly stimulatory conditions with 16.7 mM glucose, the OVXAL and OVXcycle presented lower insulin secretion versus ShamAL. Morphological analysis revealed higher iron deposition in the OVXAL islets versus OVXcycle. The results showed that ovariectomy accelerated the loss of pancreatic islet function, while weight cycling was able to restore the characteristics of the islets.
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