Unraveling the Structural Requirements of Chalcone Chemistry Towards Monoamine Oxidase Inhibition.

Due to the structural versatile, chalcones are considered as multi-targeted scaffold for the variety of enzyme targets. The present perspective focused our attention onto the monoamine oxidase inhibitory activity of synthetic chalcones which is synthesized in our lab recently. The studies clearly demonstrated that most of the chalcones showed selective, reversible and potent MAO-B inhibition compared to MAO-A depending upon the substituents bearing around α-β-unsaturated linker of the chalcone scaffold.