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Diagnoses of pathological states based on acetylcholinesterase and butyrylcholinesterase.
Current Medicinal Chemistry 2019 January 31
Two cholinesterases exist: acetylcholinesterase (AChE) and butyrylcholinesterase (BChE). While AChE plays a crucial role in neurotransmissions, BChE has no specific function apart of the detoxification of some drugs and secondary metabolites from plants. Thus both AChE and BChE can serve as biochemical markers of various pathologies. Poisoning by nerve agents like sarin, soman, tabun, VX, novichok and overdosing by drugs used in some neurodegenerative disorders like Alzheimer´s disease and myasthenia gravis, as well as poisoning by organophosphorus pesticides are relevant to this issue. But it appears that changes in these enzymes take place in other processes including oxidative stress, inflammation, some types of cancer and genetically conditioned diseases. In this review, the cholinesterases are introduced, mechanism of inhibitors action is explained and relations between the cholinesterases and pathologies are explained.
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