THE EFFECT OF VIBRO-ACOUSTIC STIMULATION ON CELL DYNAMICS OF INFLAMMATION IN RATS AND THE POSSIBILITIES FOR VIBROACOUSTIC SOUND THERAPY IN COMPLEX TREATMENT OF BRONCHITIS IN CHILDREN.

One of the methods of physiotherapy used in the complex treatment of various diseases is vibroacoustic exposure (VAE), however, the anti-inflammatory effect of this factor has not been studied insufficiently. The purpose of this research was to study the effect of VAE on the cellular dynamics of the inflammation focus. The experimental study was performed on 72 male Wistar rats weighing 180-200 g. The age of the rats was 1-1.5 months. All painful and stressful procedures were performed under ether drug (according to the European Convention for the Protection of Vertebrate Animals (Strasbourg, 08.03.1986). Acute aseptic inflammation of the soft tissues of the thigh of rats was caused by injection of 5 mg λ-caraginen («Sigma». USA) in 1 ml of isotonic sodium chloride solution The animals were sacrificed by decapitation at different periods of inflammation The main and control groups consisted of 36 animals in each group. After the introduction of λ-caraginen in the main group, animals were subjected to VAE at the area of the inflammatory focus from the Vitafon apparatus, daily, for 10 days, in 1 mode, with frequency subranges from 20 to 18000 Hz, and the amplitude of microvibration of the membrane within 2.8-8.4 microns, exposure 10 minutes. Cell-tissue dynamics in the focus of inflammation was studied after 6 hours, as well as on the 1-, 3-, 7-, and 10th days. In the control group the inflammation proceeded naturally. The results of an experimental study carried out on the rats showed that the physiotherapeutic factor VAE has an anti-inflammatory effect due to the active involving of the cellular components of physiological body protection measures. Activation of the mechanisms of sanogenesis under the influence of VAE resulted in its inclusion in the physiotherapeutic complex for the treatment of acute simple bronchitis in children, that helped to shorten the periods of their treatment. The anti-inflammatory effect of VAE consists in limiting alterative and enhancing reparative phenomena, considering that neutrophils play a leading role in the development of the inflammatory process, and monocytes-macrophages and fibroblasts - in its attenuation.